USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: ANXA2_HUMAN USC-OGP 2-DE database:  ANXA2_HUMAN ANXA2_HUMAN General information about the entry View entry in simple text format Entry name ANXA2_HUMAN Primary accession number P07355 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Annexin A2; AltName: Full=Annexin II; AltName: Full=Annexin-2; AltName: Full=Calpactin I heavy chain; AltName: Full=Calpactin-1 heavy chain; AltName: Full=Chromobindin-8; AltName: Full=Lipocortin II; AltName: Full=Placental anticoagulant protein IV; Short=PAP-IV; AltName: Full=Protein I; AltName: Full=p36;. Gene name Name=ANXA2 Synonyms=ANX2, ANX2L4, CAL1H, LPC2D Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1216: pI=6.30; Mw=36464 SPOT OGP-1219: pI=6.47; Mw=36158 SPOT OGP-1224: pI=6.85; Mw=35254 SPOT OGP-1231: pI=7.18; Mw=33988 SPOT OGP-1255: pI=6.66; Mw=30628 SPOT OGP-1270: pI=6.97; Mw=28628 SPOT OGP-1280: pI=5.93; Mw=26725 SPOT OGP-1285: pI=5.42; Mw=25688 Cross-references UniProtKB/Swiss-Prot P07355; ANXA2_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name ANXA2_HUMAN Primary accession number P07355 Secondary accession number(s) Q567R4 Q6N0B3 Q8TBV2 Q96DD5 Q9UDH8 Sequence was last modified on  January 23, 2007 (version 2) Annotations were last modified on  March 15, 2017 (version 210) Name and origin of the protein Description RecName: Full=Annexin A2; AltName: Full=Annexin II; AltName: Full=Annexin-2; AltName: Full=Calpactin I heavy chain; AltName: Full=Calpactin-1 heavy chain; AltName: Full=Chromobindin-8; AltName: Full=Lipocortin II; AltName: Full=Placental anticoagulant protein IV; Short=PAP-IV; AltName: Full=Protein I; AltName: Full=p36; Gene name Name=ANXA2 Synonyms=ANX2, ANX2L4, CAL1H, LPC2D Encoded on Name=ANXA2; Synonyms=ANX2, ANX2L4, CAL1H, LPC2D Keywords 3D-structure; Acetylation; Alternative splicing; Annexin; Basement membrane; Calcium; Calcium/phospholipid-binding; Complete proteome; Direct protein sequencing; Extracellular matrix; Isopeptide bond; Phosphoprotein; Polymorphism; Reference proteome; Repeat; RNA-binding; Secreted; Ubl conjugation. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL D00017; BAA00013.1; -; mRNA EMBL BT007432; AAP36100.1; -; mRNA EMBL BX640598; CAE45704.1; -; mRNA EMBL AC087385; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL BC001388; AAH01388.1; -; mRNA EMBL BC009564; AAH09564.1; -; mRNA EMBL BC015834; AAH15834.1; -; mRNA EMBL BC016774; AAH16774.1; -; mRNA EMBL BC021114; AAH21114.1; -; mRNA EMBL BC023990; AAH23990.1; -; mRNA EMBL BC052558; AAH52558.1; -; mRNA EMBL BC052567; AAH52567.1; -; mRNA EMBL BC066955; AAH66955.2; ALT_INIT; mRNA EMBL BC068065; AAH68065.1; -; mRNA EMBL BC093056; AAH93056.1; -; mRNA CCDS CCDS10175.1; -. [P07355-1]; . CCDS CCDS32256.1; -. [P07355-2]; . PIR A23942; LUHU36; . RefSeq NP_001002857.1; NM_001002857.1. [P07355-1]; . RefSeq NP_001002858.1; NM_001002858.2. [P07355-2]; . RefSeq NP_001129487.1; NM_001136015.2. [P07355-1]; . RefSeq NP_004030.1; NM_004039.2. [P07355-1]; . RefSeq XP_016877579.1; XM_017022090.1. [P07355-1]; . RefSeq XP_016877580.1; XM_017022091.1. [P07355-1]; . UniGene Hs.511605; -; . PDB 1W7B; X-ray; 1.52 A; A=1-339 PDB 1XJL; X-ray; 2.59 A; A/B=21-339 PDB 2HYU; X-ray; 1.86 A; A=32-339 PDB 2HYV; X-ray; 1.42 A; A=32-339 PDB 2HYW; X-ray; 2.10 A; A/B=32-339 PDB 4DRW; X-ray; 3.50 A; A/B/C/D=2-16 PDB 4FTG; X-ray; 2.51 A; C/D=2-16 PDB 4HRH; X-ray; 3.00 A; A/B=2-16 PDBsum 1W7B; -; . PDBsum 1XJL; -; . PDBsum 2HYU; -; . PDBsum 2HYV; -; . PDBsum 2HYW; -; . PDBsum 4DRW; -; . PDBsum 4FTG; -; . PDBsum 4HRH; -; . ProteinModelPortal P07355; -; . SMR P07355; -; . BioGrid 106799; 110; . IntAct P07355; 52; . MINT MINT-1213203; -; . STRING 9606.ENSP00000346032; -; . ChEMBL CHEMBL1764938; -; . DrugBank DB00031; Tenecteplase; . TCDB 1.A.31.1.4; the annexin (annexin) family; . iPTMnet P07355; -; . PhosphoSitePlus P07355; -; . SwissPalm P07355; -; . BioMuta ANXA2; -; . DMDM 113950; -; . DOSAC-COBS-2DPAGE P07355; -; . REPRODUCTION-2DPAGE IPI00455315; -; . REPRODUCTION-2DPAGE P07355; -; . UCD-2DPAGE P07355; -; . EPD P07355; -; . MaxQB P07355; -; . PaxDb P07355; -; . PeptideAtlas P07355; -; . PRIDE P07355; -; . TopDownProteomics P07355-1; -. [P07355-1]; . DNASU 302; -; . Ensembl ENST00000332680; ENSP00000346032; ENSG00000182718. [P07355-2]; . Ensembl ENST00000396024; ENSP00000379342; ENSG00000182718. [P07355-1]; . Ensembl ENST00000421017; ENSP00000411352; ENSG00000182718. [P07355-1]; . Ensembl ENST00000451270; ENSP00000387545; ENSG00000182718. [P07355-1]; . GeneID 302; -; . KEGG hsa:302; -; . UCSC uc002agk.4; human. [P07355-1]; . CTD 302; -; . DisGeNET 302; -; . GeneCards ANXA2; -; . HGNC HGNC:537; ANXA2; . HPA CAB004311; -; . MIM 151740; gene; . neXtProt NX_P07355; -; . OpenTargets ENSG00000182718; -; . PharmGKB PA24827; -; . eggNOG KOG0819; Eukaryota; . eggNOG ENOG410XPUN; LUCA; . GeneTree ENSGT00760000118972; -; . HOGENOM HOG000158803; -; . HOVERGEN HBG061815; -; . InParanoid P07355; -; . KO K17092; -; . OMA FIQQDTK; -; . OrthoDB EOG091G0H6H; -; . TreeFam TF105452; -; . Reactome R-HSA-445355; Smooth Muscle Contraction; . Reactome R-HSA-6798695; Neutrophil degranulation; . Reactome R-HSA-75205; Dissolution of Fibrin Clot; . SIGNOR P07355; -; . ChiTaRS ANXA2; human; . EvolutionaryTrace P07355; -; . GeneWiki Annexin_A2; -; . GenomeRNAi 302; -; . PRO PR:P07355; -; . Proteomes UP000005640; Chromosome 15; . Bgee ENSG00000182718; -; . CleanEx HS_ANXA2; -; . ExpressionAtlas P07355; baseline and differential; . Genevisible P07355; HS; . GO GO:0035578; C:azurophil granule lumen; TAS:Reactome; . GO GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell; . GO GO:0016323; C:basolateral plasma membrane; ISS:BHF-UCL; . GO GO:0005938; C:cell cortex; IEA:Ensembl; . GO GO:0009986; C:cell surface; IDA:UniProtKB; . GO GO:0005913; C:cell-cell adherens junction; IDA:BHF-UCL; . GO GO:0005829; C:cytosol; IEA:Ensembl; . GO GO:0005769; C:early endosome; IEA:Ensembl; . GO GO:0005768; C:endosome; IDA:UniProtKB; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005576; C:extracellular region; TAS:Reactome; . GO GO:0005615; C:extracellular space; IDA:UniProtKB; . GO GO:0019897; C:extrinsic component of plasma membrane; IEA:Ensembl; . GO GO:0031902; C:late endosome membrane; IDA:UniProtKB; . GO GO:0005811; C:lipid particle; IDA:UniProtKB; . GO GO:0005765; C:lysosomal membrane; IDA:UniProtKB; . GO GO:0044354; C:macropinosome; IEA:Ensembl; . GO GO:0042470; C:melanosome; IEA:UniProtKB-SubCell; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0030496; C:midbody; IDA:UniProtKB; . GO GO:0035749; C:myelin sheath adaxonal region; IEA:Ensembl; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:1990667; C:PCSK9-AnxA2 complex; IDA:BHF-UCL; . GO GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl; . GO GO:0005886; C:plasma membrane; IDA:BHF-UCL; . GO GO:0001726; C:ruffle; IEA:Ensembl; . GO GO:0042383; C:sarcolemma; IEA:Ensembl; . GO GO:0043220; C:Schmidt-Lanterman incisure; IEA:Ensembl; . GO GO:0031982; C:vesicle; IDA:UniProtKB; . GO GO:0098641; F:cadherin binding involved in cell-cell adhesion; IDA:BHF-UCL; . GO GO:0005509; F:calcium ion binding; IEA:InterPro; . GO GO:0005544; F:calcium-dependent phospholipid binding; IDA:UniProtKB; . GO GO:0048306; F:calcium-dependent protein binding; IPI:AgBase; . GO GO:0005546; F:phosphatidylinositol-4; 5-bisphosphate binding; IMP:UniProtKB GO GO:0019834; F:phospholipase A2 inhibitor activity; IDA:UniProtKB; . GO GO:0002020; F:protease binding; IPI:BHF-UCL; . GO GO:0003723; F:RNA binding; IDA:UniProtKB; . GO GO:0044548; F:S100 protein binding; IPI:UniProtKB; . GO GO:0001525; P:angiogenesis; IEP:UniProtKB; . GO GO:0007589; P:body fluid secretion; IEA:Ensembl; . GO GO:0030199; P:collagen fibril organization; IEA:Ensembl; . GO GO:0042730; P:fibrinolysis; IEA:Ensembl; . GO GO:0006900; P:membrane budding; IMP:UniProtKB; . GO GO:0001765; P:membrane raft assembly; IMP:UniProtKB; . GO GO:0032804; P:negative regulation of low-density lipoprotein particle receptor catabolic process; IDA:BHF-UCL; . GO GO:0043312; P:neutrophil degranulation; TAS:Reactome; . GO GO:0036035; P:osteoclast development; IDA:UniProtKB; . GO GO:0048146; P:positive regulation of fibroblast proliferation; IEA:Ensembl; . GO GO:1905581; P:positive regulation of low-density lipoprotein particle clearance; IDA:BHF-UCL; . GO GO:1905597; P:positive regulation of low-density lipoprotein particle receptor binding; IDA:BHF-UCL; . GO GO:1905599; P:positive regulation of low-density lipoprotein receptor activity; IMP:BHF-UCL; . GO GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl; . GO GO:0001921; P:positive regulation of receptor recycling; IDA:BHF-UCL; . GO GO:1905602; P:positive regulation of receptor-mediated endocytosis involved in cholesterol transport; IDA:BHF-UCL; . GO GO:0031340; P:positive regulation of vesicle fusion; IDA:UniProtKB; . GO GO:0051290; P:protein heterotetramerization; IDA:UniProtKB; . GO GO:0072661; P:protein targeting to plasma membrane; IEA:Ensembl; . GO GO:0097066; P:response to thyroid hormone; IEA:Ensembl; . Gene3D 1.10.220.10; -; 4; . InterPro IPR001464; Annexin; . InterPro IPR018502; Annexin_repeat; . InterPro IPR018252; Annexin_repeat_CS; . InterPro IPR002389; ANX2; . PANTHER PTHR10502:SF151; PTHR10502:SF151; 1; . Pfam PF00191; Annexin; 4; . PRINTS PR00196; ANNEXIN; . PRINTS PR00198; ANNEXINII; . SMART SM00335; ANX; 4; . PROSITE PS00223; ANNEXIN; 4; .

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